Neelam Dabas Sen

The paper shows that Ded1 in yeast primarily stimulates translation by unwinding 5' UTR structures, not by suppressing upstream ORF translation.

The paper shows that the synthetic growth defect in a dbp1 deletion mutant is due to loss of Dbp1, not reduced MRP51 expression from the hphMX6 marker.

The paper introduces Sel-TCP-seq to study initiation factor dynamics, revealing staged initiation and co-translational assembly of initiation complexes in yeast and human cells.

The paper shows that temperature changes affect uORF translation in S. cerevisiae, with some uORFs showing increased efficiency at higher temperatures and others showing mRNA-specific regulation.