Alan G. Hinnebusch

Molecular Architecture of the Human GCN1-ABCF3 Ribosome Collision Sensor

This study identifies ABCF3 as the mammalian ortholog of yeast Gcn20, which is recruited to ribosomes during amino acid starvation and interacts with GCN1 to activate Gcn2.

Deadenylation and Decapping Factors Cooperatively Stimulate Biochemical Activities of DEAD-Box ATPase Dhh1

This study shows that Dhh1's ATPase activity is cooperatively enhanced by deadenylation and decapping factors through distinct mechanisms.

Suppression of upstream ORF translation is not a widespread mechanism of translational stimulation by yeast helicase Ded1

The paper shows that Ded1 in yeast primarily stimulates translation by unwinding 5' UTR structures, not by suppressing upstream ORF translation.

Decapping activators Edc3 and Scd6 act redundantly with Dhh1 in post-transcriptional repression of starvation-induced pathways

The paper shows Scd6 and Edc3 redundantly work with Dhh1 to repress mRNA decay of starvation-induced pathways in yeast.

Yeast poly(A)-binding protein (Pab1) controls translation initiation in vivo primarily by blocking mRNA decapping and decay

This study shows that Pab1 in yeast primarily controls translation by blocking mRNA decapping and decay, with reduced mRNA abundance driving translational changes.

Impacts of yeast Tma20/MCTS1, Tma22/DENR and Tma64/eIF2D on translation reinitiation and ribosome recycling

The paper investigates how yeast Tma proteins affect translation reinitiation at upstream open reading frames (uORFs) and finds that their impact varies based on uORF characteristics and penultimate codons, not solely on bulk recycling dependence.

Repression of MRP51 in cis does not contribute to the synthetic growth defect conferred by an hphMX4-marked deletion of DBP1 in a ded1-ts mutant

The paper shows that the synthetic growth defect in a dbp1 deletion mutant is due to loss of Dbp1, not reduced MRP51 expression from the hphMX6 marker.

Yeast eIF2A has a minimal role in translation initiation and uORF-mediated translational control in vivo

This study investigates the role of eIF2A in yeast translation, finding minimal impact on translational efficiency and uORF-mediated control in vivo.

Decapping factor Dcp2 controls mRNA abundance and translation to adjust metabolism and filamentation to nutrient availability

This study shows that Dcp2 regulates mRNA abundance and translation to adjust metabolism and filamentation in response to nutrient availability in yeast.

Distinct functions of three chromatin remodelers in activator binding and preinitiation complex assembly

This paper investigates the roles of three chromatin remodelers in activator binding and preinitiation complex assembly in yeast, revealing their distinct and cooperative functions in nucleosome eviction and transcription regulation.

Selective Translation Complex Profiling Reveals Staged Initiation and Co-translational Assembly of Initiation Factor Complexes

The paper introduces Sel-TCP-seq to study initiation factor dynamics, revealing staged initiation and co-translational assembly of initiation complexes in yeast and human cells.

Conserved +1 translational frameshifting in the S. cerevisiae gene encoding YPL034W

The paper identifies a fourth yeast gene, YPL034W, that uses conserved +1 translational frameshifting for functional protein expression.

eIF3b and eIF3i relocate together to the ribosomal subunit interface during translation initiation and modulate start codon selection

The paper shows eIF3b and eIF3i move to the ribosomal subunit interface during translation initiation and affect start codon selection in yeast.

Temperature-Dependent Regulation of Upstream Open Reading Frame Translation in S. Cerevisiae

The paper shows that temperature changes affect uORF translation in S. cerevisiae, with some uORFs showing increased efficiency at higher temperatures and others showing mRNA-specific regulation.

Rps3/uS3 promotes mRNA binding at the 40S ribosome entry channel and stabilizes preinitiation complexes at start codons