Shardul D. Kulkarni

This study identifies Def1 as a cytoplasmic regulator of mRNA translation and decay by linking ribosome status to mRNA degradation through ubiquitylation.

The paper shows that the human CCR4-NOT complex suppresses pervasive transcription and retrotransposable elements by repressing transcription and stabilizing their RNAs.

The paper identifies a novel cytoplasmic function of Def1 in yeast, showing it regulates mRNA decay and synthesis rates through interactions with post-transcriptional regulators.

The paper shows that CCR4-NOT regulates gene expression and suppresses retrotransposon activation by modulating RNA decay and KZNF gene expression.

The paper shows that temperature changes affect uORF translation in S. cerevisiae, with some uORFs showing increased efficiency at higher temperatures and others showing mRNA-specific regulation.