Author

David Z. Rudner

Harvard UniversityORCID 0000-0002-0236-7143Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:bacteria (other)· 5 Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Fernando H. Ramírez‐GuadianaiD· 2 shared Jeremy D. AmoniD· 2 shared Joshua C. CofskyiD· 2 shared Yongqiang GaoiD· 2 shared Andrew C. KruseiD· 1 shared Anna P. BroganiD· 1 shared Briana L. SobecksiD· 1 shared Daniel B. KearnsiD· 1 shared

Activity by Year

2026-2026 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

Fernando H. Ramírez‐GuadianaORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structure of Bacillus cereus ZmaM, a peptidase-ABC transporter that secretes and activates zwittermicin A

Gerardo E Zavala, José A Velilla, Richard M Walsh, Mit Patel, Karissa Mennes, Wasan Rafat, Miguel A Aguilar Ramos, Martin Daniel-Ivad, Fernando H Ramirez-Guadiana, David Z Rudner, Emily P Balskus, Rachelle Gaudet

The paper structures ZmaM, a type II peptidase-ABC transporter in B. cereus, showing it activates and exports zwittermicin A by coordinating peptidase and transporter modules.

bioRxiv · Nov 2, 2026 · PreprintMicrobiology

Efficient septum formation is essential for chromosome segregation in Bacillus subtilis when SMC function is impaired

Nicole T Lai, Laura C. Lastra, Kehinde Oreoluwa Adebiyi, David Z. Rudner, Stephen C. Jacobson, Daniel B. Kearns, Xindan Wang

This study identifies minJ and divIVA as essential for chromosome segregation in Bacillus subtilis when SMC function is impaired, highlighting the interdependence between chromosome segregation and cell division.

Journal of Bacteriology · Oct 6, 2026Peer-reviewedMicrobiology

Structural basis for nutrient-activated channel opening in bacterial spore germination receptors

Joshua C. Cofsky, Fernando H. Ramírez‐Guadiana, Briana L. Sobecks, Lior Artzi, Jeremy D. Amon, Yongqiang Gao, Ron O. Dror, Josefina Inés del Mármol, David Z. Rudner, Andrew C. Kruse

The paper reports cryo-EM structures of GerA, revealing how nutrient binding triggers channel opening through allosteric switches and subunit interactions.

bioRxiv · Aug 27, 2026 · PreprintBiophysics

Microbial GAIN domains undergo autoproteolysis and enable release of diverse cell surface associated proteins

Anna P. Brogan, David Z. Rudner

The paper identifies microbial GAIN domains (MAIN) that undergo autoproteolysis, enabling release of surface-associated proteins in response to shear force.

Current Biology · Aug 18, 2026Peer-reviewedMicrobiology

Bacillus subtilis YpeB holds SleB inactive preventing cortex peptidoglycan degradation during spore dormancy

Yongqiang Gao, Jeremy D. Amon, Joshua C. Cofsky, David Z. Rudner

This paper shows YpeB inhibits SleB in dormant Bacillus subtilis spores through direct interaction, preventing premature cortex degradation.

mBio · Aug 7, 2026Peer-reviewedMicrobiology