Yuri I. Wolf

The paper investigates how phosphorylated nucleotides like remdesivir triphosphate and ppGpp activate SARS-CoV-2 RdRp through allosteric mechanisms involving the NiRAN domain and Nsp7/8 subunits.

The paper expands the phylogenetic and metabolic diversity of Asgard archaea and suggests eukaryotes may have originated from an unknown ancestral lineage outside extant archaea.

The paper identifies EVE and DCD domains that recognize modified bases in DNA and RNA, linking them to programmed cell death, cell cycle control, and the piRNA pathway across prokaryotes and eukaryotes.

This paper uses LSTMs to model mutational time series in cancer, predicting mutation occurrence and identifying conditional drivers and their interactions.

The paper analyzes the stability of host-parasite coevolution models and finds that stable coexistence requires the parasite to be substantially derived from the host.

The paper develops a computational method to identify genes likely functionally linked to CRISPR-Cas systems, identifying 80 previously undetected candidate genes, many associated with membrane and signal transduction.