Tom Macpherson

This study shows that inhibiting CD38 boosts NAD levels, reversing a harmful cycle of inflammation and reduced intracrine activity in aged meibomian glands.

This paper introduces a machine-learning framework to estimate latent world-model dynamics from behavioral data and applies it to analyze insight-like shifts in mouse behavior.

The paper introduces GT-SPARCL, a genetic method for low-density neuronal labeling in mice, and applies it to reveal morphological subtypes of AVP neurons in the SCN.

This study shows that Gz G-protein regulates the duration of circadian rest time by modulating cAMP-PKA activity and transcriptome remodeling in the SCN.

The paper identifies translational regulation of GAD1 in the mouse SCN using Ribo-seq and RNA-seq, showing light-induced ribosome binding without mRNA changes.

The paper shows that dopamine neurons in the mesolimbic pathway encode the value of water and salt in a state-dependent manner, influencing behavior and simulated by a reinforcement learning model.

This study investigates sex-dependent effects of nicotine on discrimination learning and cognitive flexibility in mice, finding differential impacts on visual discrimination and reversal learning tasks.

This study investigates the role of NAcD1-MSN-SNr pathway in reward learning and motor behaviors through optogenetic activation.

This study shows that dopamine D2 receptor-expressing neurons in the nucleus accumbens help mice avoid bad options during decision making by being activated after errors.