Takatoshi Hikida

This paper introduces a machine-learning framework to estimate latent world-model dynamics from behavioral data and applies it to analyze insight-like shifts in mouse behavior.

This study shows that Gz G-protein regulates the duration of circadian rest time by modulating cAMP-PKA activity and transcriptome remodeling in the SCN.

The paper shows that dopamine neurons in the mesolimbic pathway encode the value of water and salt in a state-dependent manner, influencing behavior and simulated by a reinforcement learning model.

The paper investigates the spatial organization of sensory neurons in the mouse trigeminal ganglion and finds that oral cavity representations are intermingled rather than mapped.

This study uses a Bayesian hierarchical model to decode decision-making properties from trust game data, identifying biomarkers linked to trusting behavior in MDD patients and healthy controls.

The paper identifies distinct noradrenergic subsystems in the locus coeruleus that dynamically respond to varying levels of social stress, influencing traumatic learning and anxiety.

This study uses a homeostatic reinforcement learning model to simulate how altered interoception affects reward processing and appetite in depression subtypes.

This study shows that Importin α4 deficiency in mice leads to psychiatric-like behaviors and increased neuroinflammation, with elevated NF-κB and cytokine expression.

This study investigates sex-dependent effects of nicotine on discrimination learning and cognitive flexibility in mice, finding differential impacts on visual discrimination and reversal learning tasks.

This study investigates the role of NAcD1-MSN-SNr pathway in reward learning and motor behaviors through optogenetic activation.

This paper develops a homeostatic reinforcement learning model to simulate sodium appetite behavior and explains osmoregulation as a reinforcement learning process.

This study shows that high-sucrose diets in Glo1-deficient mice cause brain angiopathy, impaired glucose uptake, and psychosis-related behaviors, with aspirin offering protection.

This study shows that dopamine D2 receptor-expressing neurons in the nucleus accumbens help mice avoid bad options during decision making by being activated after errors.

This study shows that D1 and D2 neurons in the anteromedial olfactory tubercle of mice have opposing roles in mediating attractive and aversive behaviors during place preference tests.

This study shows that the cortico-striatal circuit regulates sensorimotor gating through Disc1/Huntingtin-mediated Bdnf transport, with lithium restoring deficits in Disc1-LI mice.