BiophysicsProceedings of the National Academy of SciencesPeer-reviewed
Structural Rewiring of IL-7R Dimerization by an Oncogenic Transmembrane Mutation Can Be Reversed by Rational Design
Qian Wang, Min Chen, Asma Lasram…·James Jeiwen Chou
This study identifies an oncogenic TMD mutation in IL-7R that causes ligand-independent signaling and shows that rationally designed transmembrane helices can reverse this effect.
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