Author

James Jeiwen Chou

Chinese Academy of SciencesORCID 0000-0002-4442-0344Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:proteomics· 1

Frequent Co-Authors

Aaron Orgel· 1 shared Alyssa R. Fishbein· 1 shared Angela ChouiD· 1 shared Anton Davydenko· 1 shared Asma Lasram· 1 shared Christoph PollmanniD· 1 shared Diego Capcha-RodrigueziD· 1 shared Erez Y. LevanoniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Aaron Orgel

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2 papers

Recent·Most cited

BiophysicsProceedings of the National Academy of SciencesPeer-reviewedApr 28, 2026

Structural Rewiring of IL-7R Dimerization by an Oncogenic Transmembrane Mutation Can Be Reversed by Rational Design

Qian Wang, Min Chen, Asma Lasram…·James Jeiwen Chou

This study identifies an oncogenic TMD mutation in IL-7R that causes ligand-independent signaling and shows that rationally designed transmembrane helices can reverse this effect.

1 citation

humanproteomics

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BiochemistryNature CommunicationsPeer-reviewedApr 8, 2025

PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration

Sadeem Ahmad, Tao Zou, Jihee Hwang…·Sun Hur

This study shows PACT inhibits PKR activation by endogenous dsRNA through restricting PKR movement on dsRNA, without sequestering dsRNA, thereby adjusting the activation threshold for long dsRNA.

28 citationstop 1%

humanexperimental assay

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