Loss of Mast cells and histaminergic signaling link diet to platelet-mediated NETosis and mammary cancer recurrence
Claire P. Schane, Adam T. Nelczyk, C Chen, Jiyoung Seo, Yu Wang, Natalia Krawczyńska, Shruti V. Bendre, Erin Weisser, Dhanya Pradeep, Hashni Epa Vidana Gamage, Lara I. Kockaya, Y. Fei, Anasuya Das Gupta, Hannah Kim, Madeline A. Henn, , Erik Russell Nelson
This study links diet to mammary cancer recurrence via mast cell loss and histaminergic signaling, showing that H2R antagonists promote platelet-mediated NETosis and reemergence from dormancy.
bioRxiv · Apr 15, 2026 · PreprintCancer Biology