John O’Brien

This study shows that reducing electrical synapse coupling in retinal circuits is necessary for optimal daylight vision.

The paper identifies the proteome of electrical synapses in retinal neurons using BioID in mice and zebrafish, revealing new interactors and their roles in synapse function.

This study identifies molecular determinants of weak PDZ1/Cx36 interactions, showing that specific residues and phosphorylation regulate electrical synapse stability.

This study identifies master regulator genes involved in rod photoreceptor regeneration from endogenous progenitors in zebrafish retinas using single-cell RNA sequencing and gene knockdown experiments.

This study identifies the C-terminal region of Cx36 as critical for its transport from the ER to the Golgi via interactions with COPII and Grasp55.

This study identifies Neurobeachin's role in restricting electrical synapse proteins to dendrites in zebrafish neurons.

This study analyzes single-cell transcriptomes of wild-type and P23H mutant zebrafish retinas to identify transcriptional changes during retinal degeneration.

The paper examines how somatic mutation distributions vary across chromatin folding domains in cancer genomes, revealing distinct patterns associated with different mutational processes.

The paper identifies a genetic basis for molecular asymmetry at vertebrate electrical synapses in zebrafish, showing that two Connexins function presynaptically and postsynaptically, respectively, and are required for escape responses.