The paper investigates the functional organization of electrical synapses in zebrafish, revealing that Cx34.1 is obligatory while Cx34.7 is accessory, with roles defined by the postsynaptic scaffold, similar to chemical synapses.

bioRxiv · May 20, 2026 · PreprintNeuroscience

Uncovering the electrical synapse proteome in retinal neurons via in vivo proximity labeling

Stephan Tetenborg, Eyad Shihabeddin, Elizebeth Olive Akansha Manoj Kumar, Crystal Sigulinsky, Karin Dedek, Ya‐Ping Lin, Fabio Andres Echeverry, Hannah Hoff, Alberto E. Pereda, Bryan William Jones, Christophe Ribelayga, Klaus Ebnet, Ken Matsuura, John O’Brien

The paper identifies the proteome of electrical synapses in retinal neurons using BioID in mice and zebrafish, revealing new interactors and their roles in synapse function.

eLife · May 20, 2026Peer-reviewedNeuroscience

Neurobeachin controls the asymmetric subcellular distribution of electrical synapse proteins

E. Anne Martin, Jennifer J. Carlisle Michel, Jane S. Kissinger, Fabio Andres Echeverry, Ya‐Ping Lin, John O’Brien, Alberto E. Pereda, Adam C. Miller

This study identifies Neurobeachin's role in restricting electrical synapse proteins to dendrites in zebrafish neurons.

Current Biology · May 1, 2023Peer-reviewedNeuroscience

A forward genetic screen identifies Dolk as a regulator of startle magnitude through the potassium channel subunit Kv1.1

Joy H. Meserve, Jessica C. Nelson, Kurt C. Marsden, Jerry Hsu, Fabio Andres Echeverry, Roshan A. Jain, Marc A. Wolman, Alberto E. Pereda, Michael Granato

This study identifies eight genes, including Dolk and Kv1.1, that regulate zebrafish startle behavior through a common genetic pathway, with Dolk affecting Kv1.1 protein localization.

PLoS Genetics · Jun 1, 2021Peer-reviewedNeuroscience

Electrical synaptic transmission requires a postsynaptic scaffolding protein

Abagael M. Lasseigne, Fabio Andres Echeverry, Sundas Ijaz, Jennifer J. Carlisle Michel, E. Anne Martin, Audrey J. Marsh, Elisa Trujillo, Kurt C. Marsden, Alberto E. Pereda, Adam C. Miller

The paper shows that ZO1, a scaffolding protein, is required for Connexin localization at electrical synapses, which is necessary for functional gap junctions and synaptic transmission.

eLife · Apr 28, 2021Peer-reviewedNeuroscience