Author

Victoria T. Le

Salk Institute for Biological Studies

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Organism:human· 3 Assay:whole-genome sequencing· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Jesse R. DixoniD· 3 shared Dmitry A. GordeniniD· 2 shared Kadir Caner AkdemiriD· 2 shared Kin ChaniD· 2 shared Leszek J. KlimczakiD· 2 shared P. Andrew FutrealiD· 2 shared Peter J. CampbelliD· 2 shared Roel G.W. VerhaakiD· 2 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersGenomics

Jesse R. DixonORCID

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Author profile →

3 papers

Recent·Most cited

Spatial Genome Organization as a Framework for Somatic Alterations in Human Cancer

Kadir Caner Akdemir, Victoria T. Le, Sahaana Chandran, Yilong Li, Roel G.W. Verhaak, Rameen Beroukhim, Peter J. Campbell, Lynda Chin, Jesse R. Dixon, P. Andrew Futreal, PCAWG Structural Variation Working Group, Kadir C. Akdemir, Eva G. Álvarez, Adrian Baez‐Ortega, Paul C. Boutros, , Ludmil B. Alexandrov

The paper examines how somatic structural variations affect TAD boundaries and gene regulation in human cancers using whole genome sequencing data.

Nature Genetics · Feb 5, 2020Peer-reviewedGenomics

Process-specific somatic mutation distributions vary with three-dimensional genome structure

Kadir Caner Akdemir, Victoria T. Le, Sarah Killcoyne, Devin A. King, Ya-Ping Li, Yanyan Tian, Akira Inoue, Samirkumar B. Amin, Frederick Scott Robinson, Rafael E. Herrera, Erica J. Lynn, Kin Chan, Sahil Seth, Leszek J. Klimczak, Moritz Gerstung, , P. Andrew Futreal

The paper examines how somatic mutation distributions vary across chromatin folding domains in cancer genomes, revealing distinct patterns associated with different mutational processes.

bioRxiv · Oct 14, 2018 · PreprintGenomics

An Integrative Framework For Detecting Structural Variations In Cancer Genomes

Jesse R. Dixon, Jie Xu, Vishnu Dileep, Ye Zhan, Fan Song, Victoria T. Le, Galip Gürkan Yardımcı, Abhijit Chakraborty, Darrin V. Bann, Yanli Wang, Royden A. Clark, Lijun Zhang, Hongbo Yang, Tingting Liu, Sriranga Iyyanki, , Feng Yue

This paper presents an integrative framework to detect structural variants in cancer genomes using multiple methods and finds that non-coding structural variation significantly impacts genome function in cancer cells.

Nature Genetics · Sep 4, 2018Peer-reviewedGenomics