Author

Shubham Dubey

St. Jude Children's Research HospitalORCID 0000-0002-0281-9306Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Shubham Dubey3 papers · University of Alabama at Birmingham

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Elizabeth H. KelloggiD· 2 shared Hailey M. WallaceiD· 2 shared Seong Guk ParkiD· 2 shared Shirin FatmaiD· 2 shared Adam T. SmileyiD· 1 shared Alexandre ZanghelliniiD· 1 shared Alfredo Jose Florez ArizaiD· 1 shared Chau-Duy-Tam VoiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Elizabeth H. KelloggORCID

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Author profile →

2 papers

Recent·Most cited

Structure of the Type I-F3 CAST holo integration complex reveals licensing mechanisms during RNA-guided DNA integration

Shirin Fatma, Shubham Dubey, Vinh H. Truong, Seong Guk Park, Hailey M. Wallace, Alfredo Jose Florez Ariza, Isabella King, Elizabeth H. Kellogg

This study determines the structure of the VchCAST holo integration complex using cryo-EM, revealing conformational licensing mechanisms for RNA-guided DNA integration.

bioRxiv · Jul 1, 2026 · PreprintBiochemistry

Programmable DNA integration with New-to-Nature tools using Computational Protein Design

Hailey M. Wallace, Seong Guk Park, Adam T. Smiley, Tuba Sevik, Shubham Dubey, Shirin Fatma, Chau-Duy-Tam Vo, Ethan Creed, Alexandre Zanghellini, Elizabeth H. Kellogg

This paper introduces NovoCAST, a new RNA-guided transposon system designed through computational protein design, enabling efficient and programmable DNA integration in human cells.

bioRxiv · May 29, 2026 · PreprintBiochemistry