Author

Seong Guk Park

St. Jude Children's Research HospitalORCID 0000-0002-5852-8858Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Elizabeth H. KelloggiD· 2 shared Hailey M. WallaceiD· 2 shared Shirin FatmaiD· 2 shared Shubham DubeyiD· 2 shared Adam T. SmileyiD· 1 shared Alexandre ZanghelliniiD· 1 shared Alfredo Jose Florez ArizaiD· 1 shared Chau-Duy-Tam VoiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Elizabeth H. KelloggORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintJul 1, 2026

Structure of the Type I-F3 CAST holo integration complex reveals licensing mechanisms during RNA-guided DNA integration

Shirin Fatma, Shubham Dubey, Vinh H. Truong…·Elizabeth H. Kellogg

This study determines the structure of the VchCAST holo integration complex using cryo-EM, revealing conformational licensing mechanisms for RNA-guided DNA integration.

DOI 10.64898/2026.07.01.735701

bacteria (other)cryo-EM

𝕏 PostBluesky

BiochemistrybioRxivPreprintMay 29, 2026

Programmable DNA integration with New-to-Nature tools using Computational Protein Design

Hailey M. Wallace, Seong Guk Park, Adam T. Smiley…·Elizabeth H. Kellogg

This paper introduces NovoCAST, a new RNA-guided transposon system designed through computational protein design, enabling efficient and programmable DNA integration in human cells.

1 citation

humanDNA methylation

𝕏 PostBluesky