Shirin Fatma

This study determines how the I-F3 CRISPR-associated transposase recognizes and pairs transposon ends for transposition using cryo-EM and biochemical analyses.

The paper identifies Pucsar, a bacterial antiphage system that uses 3,5-cGMP generated by a cyclase to activate TIR effectors through a stepwise filament assembly process.

This study determines the structure of the VchCAST holo integration complex using cryo-EM, revealing conformational licensing mechanisms for RNA-guided DNA integration.

This paper introduces NovoCAST, a new RNA-guided transposon system designed through computational protein design, enabling efficient and programmable DNA integration in human cells.

This study identifies a PrfH subfamily that rescues both damaged and intact ribosomes stalled in translation, revealing dual mechanisms for peptide hydrolysis.

This study characterizes RlaP family nucleotidyltransferases from Pseudomonas species, showing they repair damaged RNAs by adding nucleotides and are essential for RNA function restoration.