This study identifies a dietary lipid axis driven by linoleic acid and FADS2 that suppresses antitumor immunity in liver cancer, offering a therapeutic target for immunotherapy resistance.

bioRxiv · Jun 26, 2026 · PreprintCancer Biology

Histone methyl-transferase G9a inhibition boosts the efficacy of immune checkpoint inhibitors in experimental hepatocellular carcinoma

Elena Adán-Villaescusa, Borja Castelló-Uribe, Iker Uriarte, Eva Santamaría, Roberto Barbero, Miriam Belzunce, Amaya López-Pascual, Maria Ujue Latasa, Jasmin Elurbide, Emiliana Valbuena-Goiricelaya, Agavni Mesropian, Guillem Cano-Segarra, Ana Hernández de Sande, Lorenzo Nevi, Simone Carotti, , Maite G Fernandez-Barrena

This study shows that inhibiting G9a enhances the effectiveness of immune checkpoint inhibitors in hepatocellular carcinoma by improving tumor immunogenicity and T cell infiltration.

Cell Reports Medicine · Mar 31, 2026Peer-reviewedPharmacology & Toxicology

Molecular insights into early malignant transition of hepatocellular carcinoma

ZhengTao ZHANG, hong li, Lingli Chen, Tao Lu, Xinyi Shentu, Yuanhua Liu, Zhixuan Tang, Shuyi Ji, Zhixin Qiu, Yining Zou, Hong Wen, Jing Han, Zhengzeng Jiang, Jie Fan, Xinbo Gao, , Lijian Hui

This study profiles early hepatocellular carcinomas to reveal molecular mechanisms of malignancy transition, identifying TERT alterations, CNA burden, and immune evasion as key factors.

Cancer Cell · Mar 26, 2026Peer-reviewedCancer Biology