Regina Hoo

Early infection response of the first trimester human placenta at single-cell scale

This study uses single-cell transcriptomics to map the early placental response to three pathogens in first-trimester human placenta, identifying coordinated inflammatory responses and pathogen-specific effects.

Automatic cell type harmonization and integration across Human Cell Atlas datasets

CellHint harmonizes cell types across Human Cell Atlas datasets, revealing new cell states and providing a cross-tissue database with 3.7 million cells.

X-inactivation states of single cell transcriptomes reveal cellular phylogenies in human females

The paper introduces a method to determine X-inactivation states in single-cell transcriptomes and uses it to infer cellular phylogenies in human females.

Spatially resolved single-cell multiomics map of human trophoblast differentiation in early pregnancy

This study creates a spatially resolved single-cell multiomics atlas of human trophoblast differentiation in early pregnancy, revealing key regulatory programs and cell-cell communication events involved in EVT invasion and arterial transformation.

Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro

This study maps the temporal and spatial dynamics of the human endometrium using single-cell and spatial reference maps, identifying key signaling pathways regulating cell fate in vivo and in vitro.