ImmunologybioRxivPreprint
A universal platform for simultaneous TCRα/β removal enables safer and more potent TCR therapies and autoimmune modeling
Giorgia Zanetti, Mateusz Legut, Austin Chen…·Mohsen Khosravi Maharlooei
This paper presents a CRISPR-based platform that removes endogenous TCRα/β chains to enhance transgenic TCR function and safety in T-cell therapies and autoimmune modeling.
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