Author

Giorgia Zanetti

Columbia University Irving Medical CenterORCID 0000-0002-3194-0877Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Hao Wei LiiD· 2 shared Megan SykesiD· 2 shared Mohsen Khosravi MaharlooeiiD· 2 shared Amber N. Wolabaugh· 1 shared Andrew Kelvin SewelliD· 1 shared Anjali SaqiiD· 1 shared Audrey V. ParentiD· 1 shared Austin CheniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

Hao Wei LiORCID

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2 papers

Recent·Most cited

A novel model demonstrating that human immune cells promote multiorgan SARS-CoV-2 dissemination and human T cells limit anti-viral innate immunity

Amber N. Wolabaugh, Vrushali V. Agashe, Zicheng Wang, Nichole M. Danzl, Christopher A. Parks, Mohsen Khosravi Maharlooei, Xiaolan Ding, Hao Wei Li, Candace D. Castagna, Giorgia Zanetti, Katherine D. Long, Yasmeen S. Saad, Anjali Saqi, Moriya Tsuji, Megan Sykes

This paper develops a human immune system mouse model to study SARS-CoV-2 dissemination and immune responses, finding that human T cells suppress innate immunity and allow viral persistence.

bioRxiv · Jun 19, 2026 · PreprintImmunology

A universal platform for simultaneous TCRα/β removal enables safer and more potent TCR therapies and autoimmune modeling

Giorgia Zanetti, Mateusz Legut, Austin Chen, Farshid Fathi, Nathan Suek, Nato Teteloshvili, Hao Wei Li, Xiaolan Ding, Daniel Traum, Klaus H. Kaestner, Ryan E. Hoang, Edwin Bremer, Andrew Kelvin Sewell, Audrey V. Parent, Rémi J. Creusot, , Mohsen Khosravi Maharlooei

This paper presents a CRISPR-based platform that removes endogenous TCRα/β chains to enhance transgenic TCR function and safety in T-cell therapies and autoimmune modeling.

bioRxiv · Feb 20, 2026 · PreprintImmunology