Anne Ndungu

A systems-based approach to uterine fibroids identifies differential splicing associated with abnormal uterine bleeding

The paper integrates multi-omics data from uterine fibroids, myometrium, and endometrium to identify differential splicing and molecular pathways associated with abnormal uterine bleeding.

The Association between Endometriosis and Immunological diseases

This study investigates the genetic and phenotypic associations between endometriosis and 31 immunological diseases using UK Biobank data, finding significant genetic correlations and a causal link with rheumatoid arthritis.

The Trans-Ancestral Genomic Architecture of Glycaemic Traits

This study identifies 242 genetic loci for glycaemic traits using trans-ancestry meta-analysis, finding 99 novel loci and improved fine-mapping resolution compared to single-ancestry analyses.

A multi-tissue transcriptome analysis of human metabolites guides the interpretability of associations based on multi-SNP models for gene expression

This study evaluates multi-SNP transcriptome-wide association models for gene expression in human tissues and their ability to identify causal genes for metabolites.

Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries

This study identifies rare genetic variants associated with type 2 diabetes using exome sequencing of 20,791 cases and 24,440 controls, and provides a Bayesian framework to improve variant prioritization.