Author

Esteban Garita

Beth Israel Deaconess Medical CenterORCID 0000-0002-0334-658XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Organism:Xenopus· 1

Frequent Co-Authors

Ahmed RattaniiD· 1 shared Cora E. AndersoniD· 1 shared Heaji ShiniD· 1 shared Jiuchun ZhangiD· 1 shared Marc W. KirschneriD· 1 shared Ömer H. YilmaziD· 1 shared Saleh KhawalediD· 1 shared Shinya Imada· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

Ahmed RattaniORCID

Mutual co-authors in cluster

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1 paper

Recent·Most cited

The Wnt/APC destruction complex targets SREBP2 in a β-catenin-independent pathway to control cholesterol metabolism

Ahmed Rattani, Cora E. Anderson, William V. Trim, Esteban Garita, Shinya Imada, Saleh Khawaled, Heaji Shin, Jiuchun Zhang, Ömer H. Yilmaz, Marc W. Kirschner

This study identifies SREBP2 as a direct APC-AXIN1 substrate degraded via a β-catenin-independent pathway, regulating cholesterol metabolism and providing a target for APC-mutant colorectal cancer.

bioRxiv · Oct 12, 2025 · PreprintBiochemistry