Heaji Shin

This study shows pancreatic cancer disrupts normal pancreatic function, leading to systemic nutrient depletion and muscle wasting, with autophagy in muscle playing a key role in nutrient redistribution to support tumor growth.

This study identifies SREBP2 as a direct APC-AXIN1 substrate degraded via a β-catenin-independent pathway, regulating cholesterol metabolism and providing a target for APC-mutant colorectal cancer.

This study shows that dietary cysteine improves intestinal stem cell repair through IL-22 from CD8+ T cells.

This study shows that intestinal stem cells (ISCs) enhance local mucosal immunity by engulfing apoptotic bodies, which leads to increased T cell activity through TNF signaling.

The paper investigates PUF RNA-binding protein partnerships with intrinsically disordered proteins in C. elegans germline stem cells, showing their role in RNA repression and self-renewal.

The paper identifies genes that function redundantly with lst-1 or sygl-1 to maintain C. elegans germline stem cells through genetic screens.

The paper identifies a PUF hub of four PUF proteins and two partners that drive self-renewal in C. elegans germline stem cells, explaining the milder defect in FBF mutants.

The paper identifies regions in the C. elegans LST-1 protein that mediate its function in stem cell self-renewal through interaction with the FBF RNA-binding protein.