Author

Shinya Imada

Koch Institute for Integrative Cancer Research At MIT

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Ömer H. YilmaziD· 3 shared Ankur JainiD· 2 shared Heather R. KeysiD· 2 shared Luke S. FerroiD· 2 shared Pushkal SharmaiD· 2 shared Rachel AndersoniD· 2 shared Saleh KhawalediD· 2 shared Tenzin KunchokiD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersMolecular Biology

Ömer H. YilmazORCID

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Author profile →

4 papers

Recent·Most cited

Polyamines buffer labile iron to suppress ferroptosis

Pushkal Sharma, Heather R. Keys, Ryan P. Mansell, Jillian Stark, Louisa Girard, Christalyn Ausler, Rachel Anderson, Sebastian Müller, Shinya Imada, Ivan Susin Pires, Tenzin Kunchok, Millenia Waite, Bingbing Yuan, Amy Deik, Luke S. Ferro, , Ankur Jain

This study shows polyamines buffer labile iron to suppress ferroptosis by linking polyamine metabolism to iron homeostasis through a genome-wide CRISPR screen and fluorescent reporter.

Cell · Aug 14, 2026Peer-reviewedCell Biology

Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis

Alberto Minetti, Omid Omrani, Christiane Brenner, Feyza Cansiz, Shinya Imada, Jonas Rösler, Saleh Khawaled, Gabriele Allies, Sven W. Meckelmann, Nadja Gebert, Ivonne Heinze, Norman Rahnis, Jing Nan Lu, Katrin Spengler, Seyed Mohammad Mahdi Rasa, , Alessandro Ori‬‬

This study identifies polyamines as key regulators of epithelial regeneration in aged intestines, showing they enhance protein homeostasis and restore regenerative capacity through dietary manipulation.

Nature Cell Biology · Nov 24, 2025Peer-reviewedMolecular Biology

The Wnt/APC destruction complex targets SREBP2 in a β-catenin-independent pathway to control cholesterol metabolism

Ahmed Rattani, Cora E. Anderson, William V. Trim, Esteban Garita, Shinya Imada, Saleh Khawaled, Heaji Shin, Jiuchun Zhang, Ömer H. Yilmaz, Marc W. Kirschner

This study identifies SREBP2 as a direct APC-AXIN1 substrate degraded via a β-catenin-independent pathway, regulating cholesterol metabolism and providing a target for APC-mutant colorectal cancer.

bioRxiv · Oct 12, 2025 · PreprintBiochemistry

Genetically encoded fluorescent reporter for polyamines

Pushkal Sharma, Colin Y. Kim, Heather R. Keys, Shinya Imada, Alex B. Joseph, Luke S. Ferro, Tenzin Kunchok, Rachel Anderson, Yulin Sun, Ömer H. Yilmaz, Jing‐Ke Weng, Ankur Jain

This paper introduces a genetically encoded fluorescent reporter for real-time measurement of polyamine levels in single cells and identifies a link between mitochondrial respiration and polyamine import in Parkinson's disease.

Nature Communications · May 27, 2025Peer-reviewedCell Biology