Author

Ravi V. Desai

Gladstone InstitutesORCID 0000-0002-0336-0883Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Assay:ATAC-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:mouse· 1 Approach:statistical model· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Leor S. WeinbergeriD· 2 shared Aaron M. BlotnickiD· 1 shared Andrew P. BlairiD· 1 shared Benjamin MartiniD· 1 shared Benoit G. BruneauiD· 1 shared Dong-Woo HwangiD· 1 shared Irfan S. KathiriyaiD· 1 shared Kavitha S. RaoiD· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersSystems Biology

Leor S. WeinbergerORCID

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2 papers

Recent·Most cited

Discovery of a Cellular Mechanism Regulating Transcriptional Noise

Ravi V. Desai, Xinyue Chen, Benjamin Martin, Sonali Chaturvedi, Dong-Woo Hwang, Weihan Li, Yu Chen, Sheng Ding, Matt W. Thomson, Robert H. Singer, Robert A. Coleman, Maike M. K. Hansen, Leor S. Weinberger

The paper identifies DNA base-excision repair as a mechanism that amplifies transcriptional noise, enhancing cellular plasticity and reprogramming efficiency.

Science · Jul 22, 2021Peer-reviewedSystems Biology

Chromatin remodeler Brahma safeguards canalization in cardiac mesoderm differentiation

Swetansu K. Hota, Andrew P. Blair, Kavitha S. Rao, Kevin So, Aaron M. Blotnick, Ravi V. Desai, Leor S. Weinberger, Irfan S. Kathiriya, Benoit G. Bruneau

This study shows that Brm deletion causes identity switches in cardiac mesoderm differentiation by altering chromatin accessibility and gene expression, revealing BRM's role in safeguarding developmental canalization.

bioRxiv · Jun 3, 2020 · PreprintDevelopmental Biology