Xinyue Chen

Linker histone regulates the myeloid versus lymphoid bifurcation of multipotent hematopoietic stem and progenitors

This study shows that linker histone H1.0 regulates HSPC fate bias toward lymphoid or myeloid differentiation, with H1.0 levels decreasing in response to IFN signaling.

Sialin2 Functions as a Mammalian Nitrate Sensor to Sustain Mitochondrial Homeostasis

The paper identifies Sialin2 as a mammalian nitrate sensor that sustains mitochondrial homeostasis by activating AMPK and enhancing mitochondrial function.

Sialin2 Senses Nitrate to Activate Endosomal PI3K-AKT-NOS Signaling

This study identifies Sialin2 as a mammalian nitrate sensor that activates endosomal PI3K-AKT-NOS signaling to enhance angiogenesis and cell survival, offering new therapeutic strategies for vascular disorders.

Quantitative comparison of single-cell RNA sequencing versus single-molecule RNA imaging for quantifying transcriptional noise

This paper compares scRNA-seq and smFISH for quantifying transcriptional noise, finding that scRNA-seq algorithms generally underestimate noise compared to smFISH.

Comparative analysis between RNA-seq and single-molecule RNA FISH indicates that the pyrimidine nucleobase idoxuridine (IdU) globally amplifies transcriptional noise

The paper compares RNA-seq and single-molecule RNA FISH to show that IdU globally amplifies transcriptional noise across most genes.

Discovery of a Cellular Mechanism Regulating Transcriptional Noise

The paper identifies DNA base-excision repair as a mechanism that amplifies transcriptional noise, enhancing cellular plasticity and reprogramming efficiency.

Non-cell-autonomous promotion of pluripotency induction mediated by YAP

This study shows YAP promotes pluripotency induction non-cell-autonomously by altering secreted proteins, contrasting its cell-autonomous inhibitory role.