Robert A. Coleman

Transitory enhancement of GATA2 chromatin engagement during early erythroid differentiation

The paper uses live-cell imaging and CUT&Tag to show that GATA2 chromatin binding kinetics change during early erythroid differentiation, with a transient increase in long-lived binding.

Dynamic transcription pre-initiation complex assembly governs initiation efficiency

The paper uses live-cell imaging and kinetic analysis to show that transcription initiation efficiency is influenced by Pol II dynamics and the order of pre-initiation complex assembly.

NMNAT1 Binding at Promoters and Enhancers Couples NAD+ Synthesis to RNA Polymerase II Engagement

This study identifies NMNAT1's role in transcriptional regulation by showing its binding to gene promoters and enhancers and its impact on RNA Polymerase II occupancy.

Discovery of a Cellular Mechanism Regulating Transcriptional Noise

The paper identifies DNA base-excision repair as a mechanism that amplifies transcriptional noise, enhancing cellular plasticity and reprogramming efficiency.

Micro-Meta App: an interactive software tool to facilitate the collection of microscopy metadata based on community-driven specifications

Micro-Meta App is an open-source tool that helps collect and organize microscopy metadata according to community standards, improving reproducibility and data sharing.