Author

Cheng Lyu

Washington University in St. LouisORCID 0000-0002-0345-8143Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Abbhirami Rajagopal· 1 shared Benpeng MiaoiD· 1 shared Bo ZhangiD· 1 shared Brendan LeeiD· 1 shared C. Charles GuiD· 1 shared Chris M. McAndrewiD· 1 shared Christina A. GurnettiD· 1 shared Christina L. CostantinoiD· 1 shared

Activity by Year

2019-2020 · peak 1/yr

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10 top collaborators · 29 mutual co-author links

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1 shared paperGenomics

Abbhirami Rajagopal

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2 papers

Recent·Most cited

ATRAID regulates the action of nitrogen-containing bisphosphonates on bone.

Lauren E. Surface, Damon T. Burrow, Jinmei Li, Jiwoong Park, Sandeep Kumar, Cheng Lyu, Niki Song, Zhou Yu, Abbhirami Rajagopal, Yangjin Bae, Brendan Lee, Steven R. Mumm, C. Charles Gu, Jonathan C. Baker, Mahshid Mohseni, , Timothy R. Peterson

The paper identifies ATRAID as a gene critical for the response to nitrogen-containing bisphosphonates, showing its role in drug efficacy and resistance in osteoporosis.

Science Translational Medicine · May 20, 2020Peer-reviewedGenomics

Improving ATAC-seq Data Analysis with AIAP, a Quality Control and Integrative Analysis Package

Shaopeng Liu, Daofeng Li, Cheng Lyu, Paul M. Gontarz, Benpeng Miao, Pamela A. F. Madden, Ting Wang, Bo Zhang

The paper introduces AIAP, an ATAC-seq analysis package that improves quality control and analysis, showing increased sensitivity in peak calling and differential analysis.

bioRxiv · Jun 28, 2019 · PreprintBioinformatics