Teije Corneel Middelkoop

This study shows SEL-5/AAK1 regulates cell migration and outgrowth in C. elegans without requiring kinase activity, and identifies Wnt signaling components involved in these processes.

The paper shows that cortical pulling forces misalign the mitotic spindle with the cell's long axis, but an actomyosin-based cell rotation corrects this, aligning the spindle with the long axis, thus fulfilling Hertwig's rule.

The paper shows CYK-1/Formin activation in RhoA foci generates active torque in the actomyosin cortex, driving chiral counter-rotation and left-right symmetry breaking in C. elegans embryos.