An integrated stress response-independent role of GCN2 prevents excessive ribosome biogenesis and mRNA translation
Mónica Román-Trufero, Istvan T. Kleijn, Kevin Blighe, Jinglin Zhou, Paula Saavedra-García, Abigail Gaffar, Marilena Christoforou, Axel Bellotti, Joel M. Abrahams, Abdelmadjid Atrih, Douglas J. Lamont, Marek Gierliński, Pooja Jayaprakash, Audrey M. Michel, Eric Ofori Aboagye, , Holger W. Auner
This study identifies an ISR-independent role of GCN2 in preventing excessive ribosome biogenesis and mRNA translation, with implications for cancer therapy.
Life Science Alliance · Mar 3, 2025Peer-reviewedCancer Biology