Dylan I. Lee

The paper identifies cell-type-specific and continuous gene programs associated with Alzheimer's Disease across multiple racial and ethnic groups using single-nucleus RNA-seq and ATAC-seq.

The paper develops a method to analyze synaptic features of cortical interneurons, revealing synaptic heterogeneity and distinct strategies in inhibitory coverage.

The paper identifies disease-specific cell signatures in non-lesional brain tissue of MS patients using single-cell and spatial transcriptomics.

The paper maps cellular changes in the aging human brain and identifies altered multicellular communities in Alzheimer's disease using single nucleus RNA-seq and bulk RNA-seq data.

This paper presents a cellular taxonomy of the adult human spinal cord using single nucleus RNA-sequencing and spatial transcriptomics, identifying 29 glial and 35 neuronal clusters and highlighting motoneuron vulnerability to ALS.

This study identifies St18 as a transcriptional determinant specifying projection neuron identity in the MGE lineage and shows its role in regulating migration and morphology of GPe neurons.