Pallavi Gaur

Modulating the Novel miR-23b-Wnt/β-catenin Axis Strengthens Endothelial Barrier Properties

This study identifies miR-23b as a negative regulator of BBB integrity and shows that anti-miR-23b enhances barrier function through multiple signaling pathways and improves outcomes in a stroke model.

Cell type-specific associations with Alzheimer's Disease conserved across racial and ethnic groups

The paper identifies cell-type-specific and continuous gene programs associated with Alzheimer's Disease across multiple racial and ethnic groups using single-nucleus RNA-seq and ATAC-seq.

Contributions of genetic variation in astrocytes to cell and molecular mechanisms of risk and resilience to late onset Alzheimer's disease

The paper uses iPSC-derived astrocytes to study genetic risk factors for Alzheimer's disease, finding concordant molecular changes in both astrocytes and brain tissue.

Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease

The paper identifies tau filaments within extracellular vesicles from Alzheimer's disease patients using mass spectrometry and cryo-electron microscopy.

Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals novel associations with AD pathology

This study uses single-nucleus and spatial transcriptomics to identify cell type-specific associations with Alzheimer's disease pathology in human temporal cortex and white matter.

Multi-cellular communities are perturbed in the aging human brain and with Alzheimer's disease

The paper maps cellular changes in the aging human brain and identifies altered multicellular communities in Alzheimer's disease using single nucleus RNA-seq and bulk RNA-seq data.

A Cellular Taxonomy of the Adult Human Spinal Cord

This paper presents a cellular taxonomy of the adult human spinal cord using single nucleus RNA-sequencing and spatial transcriptomics, identifying 29 glial and 35 neuronal clusters and highlighting motoneuron vulnerability to ALS.

Early detection of impending cryostorage tank failure using a weight-based monitoring system

This paper demonstrates that a weight-based monitoring system can detect cryostorage tank failures earlier than temperature-based systems, providing a redundant safety mechanism for cryopreserved tissues.

Rapid preimplantation genetic screening (PGS) using a handheld, nanopore-based, DNA sequencer

This study demonstrates that a handheld nanopore sequencer can rapidly perform preimplantation genetic screening with results comparable to traditional NGS.