Author

Wouter Huiting

University Medical Center GroningenORCID 0000-0002-0371-512XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Harm H. KampingaiD· 2 shared Steven BerginkiD· 2 shared Alejandra Duque‐JaramilloiD· 1 shared David Coit· 1 shared Ellen A. A. NolleniD· 1 shared Emma GerritsiD· 1 shared Gabriel Vasata FurtadoiD· 1 shared Hein SchepersiD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Harm H. KampingaORCID

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2 papers

Recent·Most cited

Molecular BiologyeLifePeer-reviewedJan 11, 2022

Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome

Wouter Huiting, Suzanne L. Dekker, Joris CJ van der Lienden…·Steven Bergink

The paper shows that targeting ATM, ATR, or DNA topoisomerases causes widespread protein aggregation through chaperone system overload, similar to proteotoxic stress and proteinopathies.

19 citations

humanproteomics

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GeneticsbioRxivPreprintDec 22, 2021

Preserving protein homeostasis prevents motor impairment in DNA Damage Response-compromised C. elegans

Wouter Huiting, Alejandra Duque‐Jaramillo, Renée I. Seinstra…·Steven Bergink

This study shows that defects in DDR pathways in C. elegans lead to protein homeostasis loss, which can be rescued by HSP-16.2, preventing motor impairment.

DOI 10.1101/2021.12.22.473820

C. elegansprotein structure

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