Author

Suzanne L. Dekker

University Medical Center Groningen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Molecular Biology· 1

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

David Coit· 1 shared Emma GerritsiD· 1 shared Gabriel Vasata FurtadoiD· 1 shared Harm H. KampingaiD· 1 shared Hein SchepersiD· 1 shared John LaCavaiD· 1 shared Joris CJ van der LiendeniD· 1 shared Lara BarazzuoliD· 1 shared

Activity by Year

2022-2022 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

David Coit

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1 paper

Recent·Most cited

Targeting DNA topoisomerases or checkpoint kinases results in an overload of chaperone systems, triggering aggregation of a metastable subproteome

Wouter Huiting, Suzanne L. Dekker, Joris CJ van der Lienden, Rafaella Mergener, Maiara Kolbe Musskopf, Gabriel Vasata Furtado, Emma Gerrits, David Coit, Mehrnoosh Oghbaie, Luciano H. Di Stefano, Hein Schepers, Maria A.W.H. van Waarde-Verhagen, Suzanne Couzijn, Lara Barazzuol, John LaCava, , Steven Bergink

The paper shows that targeting ATM, ATR, or DNA topoisomerases causes widespread protein aggregation through chaperone system overload, similar to proteotoxic stress and proteinopathies.

eLife · Jan 11, 2022Peer-reviewedMolecular Biology