Emma Gerrits

This paper maps dementia risk genes across tissues and cell types using HPA GeneSet Explorer, revealing convergent neuronal enrichment and disease-specific modules in Alzheimer's, Lewy body, and Frontotemporal dementias.

This paper uses spatial transcriptomics to identify regional astrocyte heterogeneity in cuprizone-induced demyelination and remyelination, revealing differential gene expression patterns across brain regions.

This study shows that brain regions in glioblastoma patients exhibit signs of accelerated ageing similar to Alzheimer's disease, suggesting shared mechanisms of mitochondrial and neuronal dysfunction.

The paper shows that targeting ATM, ATR, or DNA topoisomerases causes widespread protein aggregation through chaperone system overload, similar to proteotoxic stress and proteinopathies.

The paper identifies early transcriptomic changes in brain macrophages in MS tissue, linking them to lesion development and suggesting potential therapeutic targets.

The paper profiles microglia transcriptomes in AD donors and non-demented elderly using bulk and single-cell RNA sequencing, finding no significant differences in gene expression or subcluster composition.

The paper compares gene expression profiles of demyelinated white and grey matter in MS patients, finding minimal overlap and distinct glial cell signatures.