Author

Richard H. Chapple

St. Jude Children's Research HospitalORCID 0000-0002-0375-2043Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:Bayesian inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

John B. EastoniD· 2 shared Min PaniD· 2 shared Paul GeeleheriD· 2 shared William C. WrightiD· 2 shared Allister J. LoughraniD· 1 shared Asif ZubairiD· 1 shared Bárbara dos Santos PassaiaiD· 1 shared Bensheng JuiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersCancer Biology

John B. EastonORCID

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2 papers

Recent·Most cited

Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid.

Min Pan, Yinwen Zhang, William C. Wright, Xueying Liu, Bárbara dos Santos Passaia, Duane G. Currier, Jonathan A. Low, Richard H. Chapple, Jacob A. Steele, Jon P. Connelly, Bensheng Ju, Emily M. Plyler, Meifen Lu, Allister J. Loughran, Lei Yang, , Paul Geeleher

The paper investigates RA's limited effect on primary neuroblastoma tumors but efficacy in clearing bone marrow cells, identifying BMP signaling as a key determinant of cell fate and RA sensitivity.

Nature Communications · Feb 28, 2025Peer-reviewedCancer Biology

Cell type identification in spatial transcriptomics data can be improved by leveraging cell-type-informative paired tissue images using a Bayesian probabilistic model.

Asif Zubair, Richard H. Chapple, Sivaraman Natarajan, William C. Wright, Min Pan, Hyeong-Min Lee, Heather S. Tillman, John B. Easton, Paul Geeleher

Nucleic Acids Research · Apr 21, 2022Peer-reviewedBioinformatics