Author

Jonathan A. Low

St. Jude Children's Research Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Taosheng CheniD· 2 shared Aaron B. TayloriD· 1 shared Adithi DandaiD· 1 shared Allister J. LoughraniD· 1 shared Anang A. ShelatiD· 1 shared Aseem Z. AnsariiD· 1 shared Ashraf MohammediD· 1 shared Bárbara dos Santos PassaiaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

Taosheng ChenORCID

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2 papers

Recent·Most cited

BRD4 recruitment desilences transcription without erasure or depletion of repressive chromatin

Christopher J. Brandon, Sarah Robinson-Thiewes, Mangesh H. Kaulage, Wojciech Rosikiewicz, Matthew J. Cuneo, Joseph Brett, Jindpreet Kandola, Walter H. Lang, Jonathan A. Low, Ashraf Mohammed, Adithi Danda, Sam Rider, M Valentine, Jason Ochoada, Brandon Michael Young, , Aseem Z. Ansari

This study shows that BRD4 recruitment can desilence transcription within repressive chromatin without removing H3K9me3 or HP1, challenging conventional models of chromatin regulation.

bioRxiv · Apr 13, 2026 · PreprintCell Biology

Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid.

Min Pan, Yinwen Zhang, William C. Wright, Xueying Liu, Bárbara dos Santos Passaia, Duane G. Currier, Jonathan A. Low, Richard H. Chapple, Jacob A. Steele, Jon P. Connelly, Bensheng Ju, Emily M. Plyler, Meifen Lu, Allister J. Loughran, Lei Yang, , Paul Geeleher

The paper investigates RA's limited effect on primary neuroblastoma tumors but efficacy in clearing bone marrow cells, identifying BMP signaling as a key determinant of cell fate and RA sensitivity.

Nature Communications · Feb 28, 2025Peer-reviewedCancer Biology