Bensheng Ju

The paper identifies non-coding somatic variants in TAL1 regulatory regions that reactivate enhancers normally active in hematopoietic stem cells in T-lineage acute lymphoblastic leukemia.

The paper introduces BOUQUET, an algorithm that identifies 3D-super-enhancers as protein-rich cis-regulatory communities associated with co-activator condensates in mammalian cells.

The paper investigates RA's limited effect on primary neuroblastoma tumors but efficacy in clearing bone marrow cells, identifying BMP signaling as a key determinant of cell fate and RA sensitivity.

The paper identifies TCF4 and ID3 as key transcription factors driving mammary epithelial stem cell differentiation through single-cell RNA sequencing analysis.

LCA identifies subtle cell population diversity in large-scale single-cell RNA-seq data using a dual-space model with spectral clustering and technical variation control.