Author

Yu Chen

Sichuan UniversityORCID 0000-0002-8931-8079Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Yu Chen15 papers · Bristol-Myers Squibb (United States)

Biology Disciplines

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Genomics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Amanda Wheeler· 1 shared Biao DongiD· 1 shared Bin LiuiD· 1 shared Chun‐Xiao SongiD· 1 shared Dan XieiD· 1 shared Hongyun Wang· 1 shared J Liu· 1 shared Jiajie DiaoiD· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenomics

Amanda Wheeler

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2 papers

Recent·Most cited

Poly(A)-tail-length-dependent surveillance of viral RNA by PABPC1 orchestrates broad-spectrum antiviral defense

Shimin Yang, Li Zhou, Xiaoya Huang, Shunhua Zhu, Weiyi Yu, Xiao Guo, J Liu, Jikai Deng, Yuzhen Zhang, Jiejie Liu, Qianyun Liu, Ming Guo, Wenjie Xiang, Xin Wang, Zhen Zhang, , Yu Chen

This study identifies PABPC1 as a host factor that selectively targets viral RNA with short poly(A) tails, leading to degradation and antiviral defense, and develops a synthetic therapeutic based on this mechanism.

bioRxiv · Jan 13, 2026 · PreprintMicrobiology

5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages

Chun‐Xiao Song, Senlin Yin, Li Ma, Amanda Wheeler, Yu Chen, Yan Zhang, Bin Liu, Junjie Xiong, Weihan Zhang, Jian‐Kun Hu, Zong‐Guang Zhou, Biao Dong, Zhiqi Tian, Stefanie S. Jeffrey, Mei‐Sze Chua, , Stephen R. Quake

The paper analyzes 5-hydroxymethylcytosine in cell-free DNA to predict tumor types and stages with high accuracy.

Cell Research · Aug 18, 2017Peer-reviewedGenomics