Author

Federico M. Ruiz

Consejo Superior de Investigaciones CientíficasORCID 0000-0002-0385-7777Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Adrián Plaza-PeguerolesiD· 2 shared Carlos Fernández‐TorneroiD· 2 shared Alicia Santos-AledoiD· 1 shared David Gil‐CartoniD· 1 shared Dong WangiD· 1 shared Inna AphasizhevaiD· 1 shared Jun XuiD· 1 shared Marta M. Sanz MurilloiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Adrián Plaza-PeguerolesORCID

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2 papers

Recent·Most cited

Cryo-EM uncovers a sequential mechanism for RNA polymerase I pausing and stalling at abasic DNA lesions

Alicia Santos-Aledo, Adrián Plaza-Pegueroles, Marta M. Sanz Murillo, Federico M. Ruiz, Peini Hou, Jun Xu, David Gil‐Carton, Dong Wang, Carlos Fernández‐Tornero

This study uses cryo-EM to reveal a two-step mechanism of RNA polymerase I stalling at abasic DNA lesions, distinct from other lesion types.

Nature Communications · Jun 6, 2025Peer-reviewedMolecular Biology

The cryo-EM structure of trypanosome 3-methylcrotonyl-CoAcarboxylase provides mechanistic and dynamic insights into enzymatic function

Adrián Plaza-Pegueroles, Inna Aphasizheva, Ruslan Aphasizhev, Carlos Fernández‐Tornero, Federico M. Ruiz

This study presents the cryo-EM structure of trypanosome 3-methylcrotonyl-CoA carboxylase, revealing its mechanism and dynamic features relevant to drug discovery.

bioRxiv · Nov 27, 2023 · PreprintMolecular Biology