Inna Aphasizheva

This study presents the cryo-EM structure of trypanosome 3-methylcrotonyl-CoA carboxylase, revealing its mechanism and dynamic features relevant to drug discovery.

This study discovers that native MCC from Leishmania tarentolae forms filaments, determines its structure, and proposes a new model for its catalytic mechanism.

The paper introduces a toolkit for aligning and analyzing U insertion/deletion RNA editing data from kinetoplastid mitochondrial genomes.

The paper identifies KPAF4, a mitochondrial PABP in Trypanosoma brucei, which regulates mRNA editing and 3' modification by preventing premature A/U-tailing and ensuring transcript stability.