Jun Xu

This study uses cryo-EM to reveal a two-step mechanism of RNA polymerase I stalling at abasic DNA lesions, distinct from other lesion types.

This paper introduces SHERRY, a new RNA-seq method that avoids second strand synthesis by using Tn5 transposase to directly fragment and prime RNA/DNA hybrids, improving reproducibility and GC uniformity.

The paper solves a high-resolution structure of a stalled RNA polymerase II elongation complex using streptavidin affinity grids to overcome air-water interface interactions.