Gut complement C1q and C3 interact with Clostridioides difficile spores via CdeM and contribute to pathogenesis.
Marjorie Pizarro‐Guajardo, Christian Brito-Silva, Pablo Castro-Córdova, Nicolás Montes-Bravo, Eduardo Alberto Callegari, F.B. Gil, Daniel Paredes‐Sabja
This study identifies complement proteins C1q and C3 as interacting with C. difficile spores via CdeM, influencing spore entry, persistence, and recurrence of infection.
bioRxiv · Sep 25, 2026 · PreprintMicrobiology