On the discovery of ADRAM, an experience-dependent long noncoding RNA that drives fear extinction through a direct interaction with the chaperone protein 14-3-3
Xiang Li, Qiongyi Zhao, Ziqi Wang, Wei‐Siang Liau, Dean Basic, Haobin Ren, Paul Robert Marshall, Esmi Lau Zajaczkowski, Laura Jane Leighton, Sachithrani U. Madugalle, Mason R. B. Musgrove, Ambika Periyakaruppiah, Jichun Shi, Jianjian Zhang, John S. Mattick, , Timothy William Bredy
The paper identifies ADRAM, an experience-dependent lncRNA that interacts with 14-3-3 to regulate Nr4a2 expression and fear extinction memory in mice.
bioRxiv · Aug 1, 2021 · PreprintNeuroscience