Sachithrani U. Madugalle

The paper identifies C/D box snoRNAs, including orphans, that are involved in fear-related memory processes in mice by modulating mRNA methylation and synaptic function.

This study shows that mRNA-LNPs can efficiently deliver mRNA to hepatocytes in healthy and diseased livers, including tumors, suggesting potential for systemic mRNA therapy in liver cancer.

This study identifies Vaultrc5 as a noncoding RNA that regulates synaptic vault trafficking and RNA cargo dynamics, impacting learning and memory.

PSD-95-Halo-seq combined with long-read sequencing reveals sex-specific RNA isoform remodeling in excitatory synapses following fear learning.

The paper identifies local translation of circular RNAs in the prefrontal cortex of mice, revealing a micropeptide involved in synaptic activity and memory.

The paper identifies a brain-enriched extrachromosomal circular DNA (ecDNA) that regulates plasticity-related genes and is linked to fear memory stability in mice.

The paper uses Oxford Nanopore DRS to profile m6A modifications at the isoform level in human brain regions, identifying thousands of m6A sites and region-specific patterns.

The paper shows DNA G-quadruplex regulates gene expression in neurons, affecting memory formation and fear extinction.

The paper identifies a lncRNA, Gas5, involved in fear extinction by regulating RNA granule trafficking and clustering at synapses in mice.

The paper shows that inhibiting circRNA Cdr1as in the infralimbic prefrontal cortex of mice impairs fear extinction memory.

The paper identifies synapse-specific m6A RNA readers and their role in fear extinction memory consolidation through RNA immunoprecipitation and sequencing in mice.

The paper identifies ADRAM, an experience-dependent lncRNA that interacts with 14-3-3 to regulate Nr4a2 expression and fear extinction memory in mice.

This study shows ADAR1 interacts with Z-DNA during fear extinction learning, affecting RNA editing and memory flexibility.

This study shows that m6dA accumulation in DNA of prefrontal cortical neurons is linked to fear extinction learning and gene expression.