Paul Robert Marshall

Orphan C/D box snoRNAs modulate fear-related memory processes in mice

The paper identifies C/D box snoRNAs, including orphans, that are involved in fear-related memory processes in mice by modulating mRNA methylation and synaptic function.

Dynamic regulation of neuronal Vault trafficking and RNA cargo by the noncoding RNA, Vaultrc5

This study identifies Vaultrc5 as a noncoding RNA that regulates synaptic vault trafficking and RNA cargo dynamics, impacting learning and memory.

Light-inducible proximity labelling in vivo captures sex-specific RNA at excitatory synapses

PSD-95-Halo-seq combined with long-read sequencing reveals sex-specific RNA isoform remodeling in excitatory synapses following fear learning.

DNA G-quadruplex is a transcriptional control device that regulates memory

The paper shows DNA G-quadruplex regulates gene expression in neurons, affecting memory formation and fear extinction.

Fear extinction is regulated by long noncoding RNA activity at the synapse

The paper identifies a lncRNA, Gas5, involved in fear extinction by regulating RNA granule trafficking and clustering at synapses in mice.

Inhibiting circRNA Cdr1as expression in the ILPFC of adult male C57BL/6J mice impairs fear extinction memory

The paper shows that inhibiting circRNA Cdr1as in the infralimbic prefrontal cortex of mice impairs fear extinction memory.

Discovery of synapse-specific RNA N6-methyladenosine readers associated with the consolidation of fear extinction memory

The paper identifies synapse-specific m6A RNA readers and their role in fear extinction memory consolidation through RNA immunoprecipitation and sequencing in mice.

On the discovery of ADRAM, an experience-dependent long noncoding RNA that drives fear extinction through a direct interaction with the chaperone protein 14-3-3

The paper identifies ADRAM, an experience-dependent lncRNA that interacts with 14-3-3 to regulate Nr4a2 expression and fear extinction memory in mice.

Dynamic DNA structure states interact with the RNA editing enzyme ADAR1 to modulate fear extinction memory

This study shows ADAR1 interacts with Z-DNA during fear extinction learning, affecting RNA editing and memory flexibility.

The accumulation of N6-methyl-2-deoxyadenosine in DNA drives activity-induced gene expression and is required for the extinction of conditioned fear

This study shows that m6dA accumulation in DNA of prefrontal cortical neurons is linked to fear extinction learning and gene expression.

The DNA repair associated protein Gadd45g regulates the temporal coding of immediate early gene expression and is required for the consolidation of associative fear memory

This paper identifies Gadd45g as a regulator of IEG expression dynamics and memory consolidation through DNA methylation changes during fear learning.

A functional role for the epigenetic regulator ING1 in activity-induced gene expression in primary cortical neurons

This study shows that ING1 regulates activity-induced gene expression in cortical neurons by interacting with other epigenetic factors and affecting synaptic plasticity-related genes.