Laura Jane Leighton

The paper identifies C/D box snoRNAs, including orphans, that are involved in fear-related memory processes in mice by modulating mRNA methylation and synaptic function.

This study shows that mRNA-LNPs can efficiently deliver mRNA to hepatocytes in healthy and diseased livers, including tumors, suggesting potential for systemic mRNA therapy in liver cancer.

This study identifies Vaultrc5 as a noncoding RNA that regulates synaptic vault trafficking and RNA cargo dynamics, impacting learning and memory.

PSD-95-Halo-seq combined with long-read sequencing reveals sex-specific RNA isoform remodeling in excitatory synapses following fear learning.

The paper shows DNA G-quadruplex regulates gene expression in neurons, affecting memory formation and fear extinction.

The paper identifies a lncRNA, Gas5, involved in fear extinction by regulating RNA granule trafficking and clustering at synapses in mice.

The paper shows that inhibiting circRNA Cdr1as in the infralimbic prefrontal cortex of mice impairs fear extinction memory.

The paper identifies synapse-specific m6A RNA readers and their role in fear extinction memory consolidation through RNA immunoprecipitation and sequencing in mice.

The paper identifies ADRAM, an experience-dependent lncRNA that interacts with 14-3-3 to regulate Nr4a2 expression and fear extinction memory in mice.

This study shows ADAR1 interacts with Z-DNA during fear extinction learning, affecting RNA editing and memory flexibility.

This study shows that m6dA accumulation in DNA of prefrontal cortical neurons is linked to fear extinction learning and gene expression.

This study shows that knocking down Piwil1 and Piwil2 in the mouse hippocampus enhances contextual fear memory without affecting anxiety.

This paper identifies Gadd45g as a regulator of IEG expression dynamics and memory consolidation through DNA methylation changes during fear learning.

This study shows that ING1 regulates activity-induced gene expression in cortical neurons by interacting with other epigenetic factors and affecting synaptic plasticity-related genes.