ImmunologybioRxivPreprint
Context-dependent tonic signaling shapes the performance and manufacturability of a 4-1BB- based HER2 CAR-T cell therapy
Laura Angelats, Berta Marzal, Alba Rodríguez-García…·Sònia Guedan
This study shows that tonic signaling in 4-1BB-based HER2 CAR-T cells affects manufacturability and performance, with context-dependent outcomes based on manufacturing conditions.
DOI 10.64898/2026.05.11.724226