Europa Azucena González‐Navarro

This study shows that tonic signaling in 4-1BB-based HER2 CAR-T cells affects manufacturability and performance, with context-dependent outcomes based on manufacturing conditions.

This study uses single-cell multiomics to analyze CAR T cell dynamics in multiple myeloma, identifying regulatory mechanisms affecting persistence and dysfunction.

This paper develops and validates a dual-targeting CAR-T cell therapy for T-ALL that targets CCR9 and CD1a, showing improved efficacy and safety compared to single-targeting approaches.

This study integrates single-cell multi-omics data from CAR-T cells to identify factors influencing immunotherapy response in B-cell neoplasias.