Author

Álvaro Urbano-Ispizúa

Hospital Clínic de BarcelonaORCID 0000-0002-7529-9399Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alba Rodríguez-GarcíaiD· 2 shared Aleix PratiD· 2 shared Berta MarzaliD· 2 shared Guillem Colell· 2 shared Guim Cascalló· 2 shared Irene Andreu-SaumelliD· 2 shared Joan CastellsaguéiD· 2 shared Marta Giménez-AlejandreiD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersImmunology

Alba Rodríguez-GarcíaORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Context-dependent tonic signaling shapes the performance and manufacturability of a 4-1BB- based HER2 CAR-T cell therapy

Laura Angelats, Berta Marzal, Alba Rodríguez-García, Marta Español‐Rego, Teresa Lobo‐Jarne, María Hernández‐Sánchez, Guim Cascalló, Salut Colell, Marta Giménez-Alejandre, Guillem Colell, Joan Castellsagué, Irene Andreu-Saumell, Hugo Calderón, Patricia Galván, Álvaro Urbano-Ispizúa, , Sònia Guedan

This study shows that tonic signaling in 4-1BB-based HER2 CAR-T cells affects manufacturability and performance, with context-dependent outcomes based on manufacturing conditions.

bioRxiv · May 14, 2026 · PreprintImmunology

In vivo CRISPR-based screen identifies ZC3H12C as a mediator of CAR-T cell dysfunction in solid tumors

Paula Barbao, Alba Rodríguez-García, Ariel Galindo‐Albarrán, Marta Giménez-Alejandre, Pablo Clavero, Teresa Lobo‐Jarne, Marta Botas, Guillem Colell, Joan Castellsagué, Guim Cascalló, Irene Andreu-Saumell, Marta Soria-Castellano, Salut Colell, Berta Marzal, Beatriz Martín-Mur, , Sònia Guedan

The paper identifies ZC3H12C as a mediator of CAR-T cell dysfunction in solid tumors through an in vivo CRISPR screen and validates its role using single-cell RNA and ATAC-seq.

bioRxiv · May 2, 2026 · PreprintImmunology